Mac OS X Lion included a new feature called Launchpad, which brought the homescreen everyone knows and loves from iOS to the Mac. The feature is nearly identical to the homescreen on iOS devices - it has folders, pages of apps, and you can remove apps that you don't want to appear - well, some apps. Only apps that you downloaded from the Mac App Store can be removed from Launchpad. Chances are that's not too many because of the options available in the Mac App Store.
Thankfully, one developer has created a small tool that allows you to fine-tune exactly which apps will appear in Launchpad, without actually removing them from your computer. Any app can be removed, even ones you didn't download from the Mac App Store.
Simply download the tool here: http://chaosspace.de/dev/launchpad-control-hide-apps-from-launchpad/. Then, unzip the file and double-click on the install file. This file will open System Preferences and install a new pane for you to access the tool. Once you're in the pane, simply uncheck the apps you don't want to appear in Launchpad. Finally, click "Apply." Your Dock will disappear for a few seconds and then re-appear. Enter Launchpad and the app(s) that you've select to not appear in Launchpad should be gone!

